abstract：BACKGROUND/AIM:Matrix metalloproteinase 20 (MMP20) is a member of the family of matrix metalloproteinases. Under normal conditions the expression of MMP20 is restricted to ameloblasts and odontoblasts. In order to identify a possible expression of MMP20 under pathological conditions, we investigated three major human t...

journal_title：Anticancer research

authors： Kraus D,Reckenbeil J,Perner S,Winter J,Probstmeier R

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND/AIM:Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatm...

journal_title：Anticancer research

authors： Sumida T,Ishikawa A,Kamata YU,Nakano H,Yamada T,Mori Y

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:As the incidence of lung cancer in the elderly is increasing worldwide, there exists a need to develop a clinically effective, less toxic therapy for this patient population. Although erlotinib has shown proven effectiveness against non-small cell lung cancer (NSCLC), few studies have prospectively investiga...

journal_title：Anticancer research

authors： Yamada K,Azuma K,Takeshita M,Uchino J,Nishida C,Suetsugu T,Kondo A,Harada T,Eida H,Kishimoto J,Eriguchi G,Takayama K,Nakanishi Y,Sugio K

更新日期：2016-06-01 00:00:00

abstract：AIM:To report initial results of hypofractionated carbon ion radiotherapy (C-ion RT) for cholangiocarcinoma. PATIENTS AND METHODS:Data regarding seven patients with cholangiocarcinoma treated by C-ion RT were analyzed. Prescribed doses were 52.8 Gy [relative biological effectiveness (RBE)] or 60.0 Gy (RBE) in four fra...

journal_title：Anticancer research

authors： Abe T,Shibuya K,Koyama Y,Okamoto M,Kiyohara H,Katoh H,Shimada H,Kuwano H,Ohno T,Nakano T

更新日期：2016-06-01 00:00:00

abstract：:Several studies have reported that high F18-fluorodeoxyglucose (FDG) uptake is predictive of poor prognosis and aggressive features in patients with breast cancer. While these studies evaluated the prognostic value for cases with high FDG uptake, they did not elucidate the meaning of FDG negativity in primary breast c...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tsuboi M,Higuchi T,Obayashi S,Tokiniwa H,Nagaoka R,Takata D,Horiguchi J,Kuwano H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery. PATIENTS AND METHODS:Fifty consecutive patients with T2-4 GBC who underwent surgery were r...

journal_title：Anticancer research

authors： Okada K,Kawai M,Ueno M,Hirono S,Miyazawa M,Hayami S,Shimizu A,Shigekawa Y,Kitahata Y,Miyamoto A,Yamaue H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Since superparamagnetic iron oxide nanoparticles (SPION) possess unique features, they provide a huge platform for medical applications, especially for cancer diagnosis and therapy (e.g. imaging, and drug targeting). However, heterogeneous effects on mammalian cells with regard to reproductive tissue are des...

journal_title：Anticancer research

authors： Pöttler M,Hofmann S,Dürr S,Unterweger H,Wiest I,Zaloga J,Alexiou C,Jeschke U,Janko C

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilita...

journal_title：Anticancer research

authors： Kölbl AC,Wellens R,Koch J,Rack B,Hutter S,Friese K,Jeschke U,Andergassen U

更新日期：2016-06-01 00:00:00

abstract：AIM:We screened nine 1,2-dihydro-quinolines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HepG2 and SMMC cells and identified ethyl-2-cyano-2-(2- (methoxycarbonyl)allyl)quinoline-1(2H)-carboxylate (compound 5) as a potential anticancer agent. In order to further deve...

journal_title：Anticancer research

authors： Ma X,Wu YI,Yang X,Yang S,Li Y,Huang Y,Lee RJ,Bai T,Luo Y

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:S-1, an oral 5-fluorouracil (5-FU)-based medicine that combines tegafur, gimeracil and oteracil potassium is commonly used as an adjuvant chemotherapeutic drug for the treatment of colorectal cancer. PATIENTS AND METHODS:We enrolled 53 patients who underwent curative resection for colorectal cancer and live...

journal_title：Anticancer research

authors： Yamauchi K,Kokuryo T,Yokoyama Y,Uehara K,Yamaguchi J,Nagino M

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Genomic imprinting is associated with many human diseases, including various types of cancers, however, no studies on gene imprinting are related to squamous cell carcinoma of the head and neck (SCCHN) directly. MATERIALS AND METHODS:In this study, the expression of a panel of 15 imprinted genes in cancerou...

journal_title：Anticancer research

authors： Hsu CM,Lin PM,Lin HC,Lai CC,Yang CH,Lin SF,Yang MY

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND/AIM:Malignant mesothelioma is a rare malignancy with limited therapeutic options. Exome-based next-generation sequencing (NGS) techniques may direct the future of molecular targeting and improve systemic therapies for patients with mesothelioma. MATERIALS AND METHODS:Eleven patients with NGS testing were se...

journal_title：Anticancer research

authors： Ugurluer G,Chang K,Gamez ME,Arnett AL,Jayakrishnan R,Miller RC,Sio TT

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD), and the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) after PD is poor. PATIENTS AND METHODS:A multi-institutional retrospective study was performed in 174 patients who underwent PD ...

journal_title：Anticancer research

authors： Yamashita Y,Yoshizumi T,Fukuzawa K,Nishizaki T,Tsujita E,Kajiyama K,Soejima Y,Yamagata M,Yamamoto K,Adachi E,Sugimachi K,Ikeda Y,Uchiyama H,Maeda T,Itoh S,Harimoto N,Ikegami T,Maehara Y

更新日期：2016-05-01 00:00:00

abstract：AIM:To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). PATIENTS AND METHODS:The prescribed radiation dose was 30 Gy in 5 fractions over 10 day...

journal_title：Anticancer research

authors： Shikama N,Kumazaki YU,Miyazawa K,Miyaura K,Kato S,Nakamura N,Kawamori J,Shimizuguchi T,Saito N,Saeki T

更新日期：2016-05-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

journal_title：Anticancer research

authors： Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Lung cancer cells often express vimentin. However, the function of vimentin in lung cancer cells has not been fully evaluated. MATERIALS AND METHODS:We evaluated the association between vimentin expression in resected non-small cell lung cancer (NSCLC) specimens and prognosis. Short-interfering RNA targetin...

journal_title：Anticancer research

authors： Tadokoro A,Kanaji N,Liu D,Yokomise H,Haba R,Ishii T,Takagi T,Watanabe N,Kita N,Kadowaki N,Bandoh S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Drug resistance to 5-fluorouracil (5-FU) is a major obstacle in colonic cancer treatment. Activation of nuclear factor-kappa B (NFκB), mitogen-activated protein kinase kinase kinase 8 (MAP3K8) and protein kinase B (AKT) is thought to protect cancer cells against therapy-induced cytotoxicity. MATERIALS AND M...

journal_title：Anticancer research

authors： Körber MI,Staribacher A,Ratzenböck I,Steger G,Mader RM

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND/AIM:Numerous trials have described a wide variation of metabolic complications associated with the mammalian target of rapamycin inhibitors (mTORi). This analysis aimed to report and critically analyze the risks of mTORi-associated metabolic complications. MATERIALS AND METHODS:A comprehensive search of all...

journal_title：Anticancer research

authors： Lew S,Chamberlain RS

更新日期：2016-04-01 00:00:00

abstract：:We have previously reported that the presence of an extracapsular invasion (ECI) at sentinel lymph nodes (SLNs) is a strong predictor of non-SLN metastasis in breast cancer. We hypothesized that(18)F-fluorodeoxyglucose (FDG) uptake by metastatic SLNs reflects invasive disease, or ECI. In this study, we evaluated the a...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tatsuki H,Kuwano H

更新日期：2016-04-01 00:00:00

abstract：:Herein we report on a case of synchronous large gastrointestinal stromal tumor (GIST) and adenocarcinoma of the stomach treated with radical surgery following neoadjuvant therapy with imatinib mesylate. A 58-year-old man was referred to our hospital with a large mass in the peritoneal cavity. Abdominal computed tomogr...

journal_title：Anticancer research

authors： Namikawa T,Munekage E,Munekage M,Maeda M,Yatabe T,Kitagawa H,Sakamoto K,Obatake M,Kobayashi M,Hanazaki K

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The proportion of geriatric gastric cancer (GC) patients with comorbidities has been increasing in Japan. This study was designed to evaluate the prognostic influence of the extent of lymph node dissection (END) and perioperative morbidities in patients with GC. PATIENTS AND METHODS:Between 2008 and 2013, t...

journal_title：Anticancer research

authors： Kawaguchi T,Komatsu S,Ichikawa D,Kimura YU,Komiyama S,Konishi H,Kin S,Kawakami S,Kosuga T,Okamoto K,Otsuji E

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND/AIM:In this study we aimed to determine if advanced age represents a risk factor for negative perioperative and long-term outcome in patients undergoing curative surgery ductal pancreatic adenocarcinoma surgery. PATIENTS AND METHODS:Two-hundred-twenty-one consecutive patients, twelve (6%) patients ≥80 years...

journal_title：Anticancer research

authors： Marsoner K,Kornprat P,Sodeck G,Schagerl J,Langeder R,Csengeri D,Wagner D,Mischinger HJ,Haybaeck J

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Despite receiving post-operative 5-fluorouracil (5-FU)-based chemotherapy, approximately 50% of patients with stage IIIC colon cancer experience recurrence. Currently, no molecular signature can predict response to 5-FU. MATERIALS AND METHODS:Mouse models of colon cancer have been developed and characterize...

journal_title：Anticancer research

authors： Hadac JN,Miller DD,Grimes IC,Clipson L,Newton MA,Schelman WR,Halberg RB

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Pharmacologically active components of ginseng, particularly protopanaxadiol (PPD)-type ginsenosides, have potent anticancer effects, although their effects on highly malignant glioblastoma multiforme (GBM) have not been systemically evaluated. Identification of effective anticancer ginsenosides and further ...

journal_title：Anticancer research

authors： Wanderi C,Kim E,Chang S,Choi C,Choi K

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND/AIM:Neuroendocrine neoplasms (NEN) of the female genital tract account for 2% of gynecological cancers. The aim of this study was to share our experience of 11 primary neuroendocrine neoplasms of the ovary. PATIENTS AND METHODS:All patients who presented and/or were treated at our Institution with histologi...

journal_title：Anticancer research

authors： Sehouli J,Woopen H,Pavel M,Richter R,Lauterbach LK,Taube E,Darb-Esfahani S,Fotopoulou C,Pietzner K

更新日期：2016-03-01 00:00:00

abstract：AIM:To generate a survival score for patients with breast cancer treated with stereotactic radiosurgery (SRS) alone for brain metastases. PATIENTS AND METHODS:Seven factors were evaluated in 34 patients, namely age, performance score, number of brain metastases, maximum diameter of all brain metastases, location of br...

journal_title：Anticancer research

authors： Rades D,Dziggel L,Janssen S,Blanck O,Hornung D,Schild SE

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND/AIM:Mouse double minute 2 (MDM2) and prostate-specific membrane antigen (PSMA) are currently under investigation as individual therapeutic targets due to their overexpression in many cancer types, as well as their pro-tumorigenic effect on cells. Recently, knockdown of PSMA was linked to a decrease in MDM2 a...

journal_title：Anticancer research

authors： Bradbury R,Jiang WG,Cui YX

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. MATERIALS AND METHODS:Anti-TIMM17A transgenes were stably tran...

journal_title：Anticancer research

authors： Yang X,Si Y,Tao T,Martin TA,Cheng S,Yu H,Li J,He J,Jiang WG

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Transient hypocalcaemia is a frequent complication after total knee arthroplasty (TKA). In this study, we investigated the factors associated with the development of hypocalcaemia after TKA in order to explore its clinical significance and treatment. PATIENTS AND METHODS:A retrospective analysis of the chan...

journal_title：Anticancer research

authors： Gai P,Sun H,Sui L,Wang G

更新日期：2016-03-01 00:00:00

abstract：:The requirements on sunscreens have essentially changed, since some years ago it was demonstrated that approximately 50% of free radicals, that are formed in the skin by solar radiation, originate from the visible and infrared regions of the solar spectrum. In addition, a critical radical concentration threshold could...

journal_title：Anticancer research

authors： Zastrow L,Lademann J

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored. MATERIALS AND METHODS:An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (...

journal_title：Anticancer research

authors： Turunen A,Hukkanen V,Kulmala J,Syrjanen S

更新日期：2016-02-01 00:00:00

abstract：:Development of an effective therapeutic strategy for refractory pancreatic cancer must consider whether chemosensitivity can be induced in chemoresistant cells. We established a pancreatic cancer stem cell-rich cell line using TIG-1 feeder cells and leukemia inhibitory factor (LIF)-rich SNL76/7 conditioned medium. We ...

journal_title：Anticancer research

authors： Imaizumi A,Onishi H,Yamasaki A,Kawamoto M,Umebayashi M,Morisaki T,Hasumi K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND/AIM:The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). MATERIALS AND METHODS:microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays ...

journal_title：Anticancer research

authors： Winther M,Alsner J,Sørensen BS,Wittrup CF,Tramm T,Baeksgaard L,Hofland K,Holtved E,Nordsmark M

更新日期：2016-02-01 00:00:00

abstract：AIM:The purpose of the present study was to identify variables associated with high risk of failure in patients with locally advanced squamous cell carcinoma of the oral cavity (SCC-OC). PATIENTS AND METHODS:This retrospective study included 191 patients with stage III-IVb SCC-OC treated with post-operative radiothera...

journal_title：Anticancer research

authors： Noble AR,Greskovich JF,Han J,Reddy CA,Nwizu TI,Khan MF,Scharpf J,Adelstein DJ,Burkey BB,Koyfman SA

更新日期：2016-02-01 00:00:00

abstract：AIM:Eudragit® E 100 (EE100) was used to improve the transfection efficiency of polyethylenimine (PEI). MATERIALS AND METHODS:Mobility of PEI-DNA complexes with and without EE100 were visualized by agarose gel electrophoresis and their transfection efficiencies were investigated in KB human oral carcinoma cells by flow...

journal_title：Anticancer research

authors： Kanthamneni N,Yung B,Lee RJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIM:Cabazitaxel is an approved second-line treatment for docetaxel-refractory metastatic castration-resistant prostate cancer. However, the median time to progression on cabazitaxel is 2.8 months. We aimed to determine whether DNA methylation plays a role in cabazitaxel resistance. MATERIALS AND METHODS:DU1...

journal_title：Anticancer research

authors： Ramachandran K,Speer C,Nathanson L,Claros M,Singal R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIM:Atrophic gastritis (AG) is the most important risk condition for gastric cancer (GC). A panel of stomach-specific serum biomarkers: pepsinogen (PG) I, pepsinogen (PG) II, gastrin-17 (G-17), and IgG antibodies to H. pylori (HP-Ab) detects the extent and grade of AG. The aim of the present study was to ass...

journal_title：Anticancer research

authors： Kurilovich S,Belkovets A,Reshetnikov O,Openko T,Malyutina S,Ragino Y,Scherbakova L,Leja M,Paloheimo L,Syrjänen K,Voevoda M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:One of the challenges to improving access to care is identifying disparities in health care. To determine the influence of insurance status on outcome for patients with non-small cell lung cancer (NSCLC), we analyzed data from the National Cancer Data Base (NCDB) from 1998-2011. MATERIALS AND METHODS:Data f...

journal_title：Anticancer research

authors： Shi R,Diaz R,Shi Z,Duvall E,Mills G

更新日期：2016-01-01 00:00:00

abstract：AIM:To assess the outcome of patients with vulvar carcinoma unfit for surgery treated with radiotherapy for primary disease and for those with recurrent disease after primary surgery. PATIENTS AND METHODS:The study was conducted on 16 patients with primary disease and 31 with recurrent disease. RESULTS:An objective r...

journal_title：Anticancer research

authors： Laliscia C,Gadducci A,Montrone S,Tana R,Morganti R,Fabrini MG

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent different agents commonly used for the second-line treatment of patients with advanced-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We analyzed data of 137 patients with advanced-stage non-squamous NSCLC treated with pemetrexed or erlotinib in the second ...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Svaton M,Minarik M,Benesova L,Bortlicek Z,Kucera R,Topolcan O

更新日期：2016-01-01 00:00:00